Everything about Erythropoietin Receptor totally explained
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| Name = Erythropoietin receptor
| HGNCid = 3416
| Symbol = EPOR
| AltSymbols =; MGC138358
| OMIM = 133171
| ECnumber =
| Homologene = 95
| MGIid = 95408
| GeneAtlas_image1 = PBB_GE_EPOR_396_f_at_tn.png
| GeneAtlas_image2 = PBB_GE_EPOR_37986_at_tn.png
| GeneAtlas_image3 = PBB_GE_EPOR_209962_at_tn.png
| Function =
| Component =
| Process =
| Orthologs =
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The
erythropoietin receptor is a 66
kDa peptide and is a member of the
cytokine receptor family. The receptor is
tyrosine phosphorylated upon binding by
erythropoietin and associates with and activates the
tyrosine kinase,
JAK2, which activates different intracellular pathways including: Ras/MAP kinase,
phosphatidylinositol 3-kinase and
STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce
erythroleukemia and
familial erythrocytosis.
Further Information
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